A protecting group-free synthesis of the Colorado potato beetle pheromone

• Zhongtao Wu,
• Manuel Jäger,
• Jeffrey Buter and
• Adriaan J. Minnaard

Beilstein J. Org. Chem. 2013, 9, 2374–2377, doi:10.3762/bjoc.9.273

• Zhongtao Wu Manuel Jager Jeffrey Buter Adriaan J. Minnaard Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, 9747 AG, Groningen, The Netherlands 10.3762/bjoc.9.273 Abstract A novel synthesis of the aggregation pheromone of the Colorado potato beetle, Leptinotarsa

• ; catalysis; Colorado potato beetle; Leptinotarsa decemlineata; oxidation; natural product; Introduction The Colorado potato beetle Leptinotarsa decemlineata, a worldwide pest causing considerable damage in the US annually, has developed resistance to more than 25 insecticides [1][2][3][4]. For crop

• insecticides controlling the Colorado potato beetle, and an attractive alternative is to use a pheromone management strategy. An important finding in this connection was the isolation of the male produced aggregation pheromone by Dickens and Oliver et al. in 2002 [7], which was subsequently identified as (S